DIY Idebenone, Niacinamide (B3), Glucosamine anti aging serum (DragoN’s recipe)

This serum is jam packed with potent anti aging actives, antioxidants, in a skin loving base of seamollient and Borage oil.  It was created by DragoN from forum (she is an incredible wealth of skin care science knowledge), and a favourite amongst DIYers on that forum.


DIY Idebenone, Niacinamide, Glucosamine anti aging serum


Ingredient overview:


Idebenone: the powerful antioxidant found in the Prevage line of products.

Niacinamide and Glucosamine: Anti inflammatory, anti-acne,  anti aging, boosts the skin’s own hydration levels from the inside out. More detail on these actives see my previous DIY Niacinamide Glucosamine and Green Tea Serum post

Borage Seed Oil: one of my fav oils at the moment, highest GLA content out of any plant oils. For more details, see my Argan and Borage Oils post.

Hyaluronic acid: humectant -draws moisture from the environment to your skin.

Vitamin E: antioxidant, extends shelf life of oils in a product.

The Recipe:

  • Idebenone 0.15 g from                             
  • Niacinamide (B3) 1.5 g from                
  • N-Acetyl Glucosamine 0.6 g from    
  • Non Denatured Ethanol 0.15 (used to dissolve the Idebenone, and as a penetration enhancer)   not available for purchase in Australia or online. You can use 0.3g vodka instead or dissolve into the oil phase)
  • Borage oil 9.0 g                                                
  • Seamollient 9.0 g                                           
  • Vit E (Covi-Ox mixed tocopherols)0.6 g
  • Hyaluronic acid stock serum 1% 2.4 g    , premixed by me.
  • distilled water 6 g
  • Polysorbate 80 0.6 g (emulsifier)              
  • A few drops of Optiphen (preservative)  


note: the actives in this recipe are used at their maximum recommended concentrations to ensure maximum potency

DIY Idebenone, niacinamide, glucosamine serum ingredients

DIY Idebenone, niacinamide, glucosamine serum ingredients


Step by step instructions:

(You need a decent scale that is accurate to 0.01g)

1.  Measure out 0.15 g of Idebenone (put the container on the scale first and then ‘tare’, or zero it first)

DIY Idebenone, niacinamide, glucosamine serum
Exactly 0.15g of Idebenone before adding ethanol

 keep reading after the jump!

 2.  Add 0.15g of non-denatured ethanol to dissolve the Idebenone powder (zero the scale again with the container + Idebenone on it, then add the ethanol straight in). Set aside.

3.  In a separate shot glass, measure out 6g of distilled water, then add the Niacinamide and Glucosamine straight in. Stir until dissolved.

DIY Idebenone, niacinamide, glucosamine serum

Distilled water, Niacinamide, Glucosamine measured out in a shot glass


4.  In another shot glass, measure out 9g of Seamollient and 2.4g of Hyaluronic acid serum (premade to 1%- I will show you how to DIY this in the next tutorial).

DIY Idebenone, niacinamide, glucosamine serum

Measuring out the Seamollient in a shotglass

5.  Add the ingredients in step 3 and 4 together, and mix well. You end up with a shotglass with Seamollient, Hyaluronic acid, Niacinamide, Glucosamine, and water. Gel consistency.

6.  Measure out the Borage oil and add polysorbate 80 + vitamin E into it.

DIY Idebenone, niacinamide, glucosamine serum

Top left: Seamollient/Hyaluronic Acid/B3/glucosamine, Top Right: Oils/polysorbate/E, Bottom: Idebenone/Eth


7.   Mix the Idebenone/ethanol mixture into the Borage oil mixture.

DIY Idebenone, niacinamide, glucosamine serum

Idebenone, Ethanol, Borage Oil, Polysorbate 80, vitamin E

  1. Slowly add the Seamollient/Hyaluronic acid/Niacinamide/Glucosamine shot glass into the Idebenone/ethanol/borage oil/polysorbate80/vitamin E shotglass while mixing well. You should have a creamy yellowish serum.
  2. Add Optiphen (preservative) and any essential oils of your choice.
  3. If you have a small hand mixer, use this now.


DIY Idebenone, niacinamide, glucosamine serum

DIY Idebenone, niacinamide, glucosamine serum


You end up with this silky, creamy, LUXURIOUS serum with incredibly anti aging and antioxidant properties.  I use it once a day after a shower, it absorbs straight into my skin without any greasiness.

When first starting on Idebenone, it is recommended that you ease your skin into it- start every 2nd day (like you would with retinol) and then after about 10 days, depending on your skin, you can switch up to daily use.

In summer I will probably make a lighter version by decreasing the oils and increasing the hyaluronic acid 1% stock serum by the same amount.

note: You can purchase a premade 1% Hyaluronic acid serum at, but it is really expensive. Like most DIYers, I prefer making my own stock 1% Hyaluronic acid serum by buying pure Hyaluronic acid powder and making a decent sized batch every month. Stay tuned for the tutorial on how to do it later on this week!

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Posted by on May 31st, 2011 in DIY Skin Care | 21comments

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